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The median avidity of TgAb was in H, in sH and in Eu, respectively. lgaK of TgAb was of significantly lower level in Eu than in H and sH ( P 005, respectively and there was no significant difference between H and sH ( P 005).
The levels of total triiodothyronine (TT3 total tetraiodothyronine (TT4 thyroid stimulating hormone (TSH and thyroglobulin antibody (TgAb) levels and avidity in sera from patients with H, sH and Eu. Titres and avidity of TgAb Titres of TgAb in all three groups are shown in.
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The TgAb titre was defined as the maximum serum dilution from 1 : 400 to 1 : 409 600 giving a positive binding, and was expressed as logarithm value (lgT). Avidity constant determination The avidity constant (aK) was determined by antigen-inhibition ELISA s.
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Our previous work revealed that the predominant TgAb immunoglobulin (Ig)G subclasses in sera from HT patients were IgG1, IgG2 and IgG4, and patients with high titres of IgG1 and IgG2 might be at high risk of developing overt hypothyroidism, indicating that the distribution of IgG subclasses of TgAb might be involved in the disease progression.
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