Other symptoms of thyrotoxicosis include heat intolerance, weight loss, increased appetite, increased bowel movements, irregular menstrual cycle, rapid or irregular heartbeat, palpitations, tiredness, irritability, tremor, hair loss and retraction of the eyelids which results in a staring appearance.
TECHNICAL FIELD The invention relates to pharmaceutical preparations generally, and more specifically to a preparation useful in replacement therapy for thyroactive material normally supplied by the thyroid gland. BACKGROUND ART The thyroid gland, among other things, modulates a body's energy metabolism.
What happens if I have too little triiodothyronine? Hypothyroidism is the term for the production of too little thyroid hormone by the thyroid gland. This may be because of autoimmune diseases, poor iodine intake or the result of taking particular drugs.
Once such a dosage form is ingested the T-4 containing matrix would dissolve, freeing the small prolonged-release pellets of T-3 for a slow release of this hormone. The T-3 and T-4 or either of them are preferably incorporated into dosage units for oral administration.
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The preparation can be a single unit dosage form containing salts of both thyroxine and liothyronine in a molar ratio of about 10:1 (in a broad molar ratio of 1 to 50:1, and preferably of 5 to 20:1 when the levo-rotatory isomers of the compounds are used.
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It is further found that TSH level is elevated in comparison with conventional release regimens. It further decreases the confusion seen with interpreting serum thyroid hormone levels of subjects undergoing hormone replacement therapy, since the resulting thyroid hormone blood levels are similar to that seen in the "normal" population.
Triiodothyronine is a thyroid hormone that plays vital roles in the bodys metabolic rate, heart and digestive functions, muscle control, brain development and the maintenance of bones. Alternative names for triiodothyronine T3.
T-3 or T-4) calculated to produce the desired effect. The amount of T-3 and T-4 in a dosage unit will depend somewhat on the length of time the prolonged release dosage form releases T-3 and T-4 remains in the subject's system.
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13 g) of T-3 and 25 to 200 g, preferably 80-140 g (e.g. 110 g of T-4 are extremely useful in the practice of the invention. The ultimate dosage to provide physiological thyroid hormone substitution depends, apart from individual characteristics, on the degree of residual thyroid function, the gastrointestinal absorption of the preparation, the patient's.