Levothyroxine Thyro-Tabs (levothyroxine) - Lloyd Laboratories is for use in dogs for correction of conditions associated with low circulating thyroid hormone (hypothyroidism). Levothyroxine is a synthetic thyroid replacement for the hormone that the thyroid gland normally produces to regulate the body's energy and metabolism.Overdosage will result in the signs of thyrotoxicosis listed above under precautions. Dosage: The initial recommended dose is 0.1mg/10lb (4.5kg) body weight twice daily. Dosage is then adjusted by monitoring the thyroid blood levels of the dog every four weeks until an adequate maintenance dose is established.
Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Adverse Reactions. There are no particular adverse reactions associated with levothyroxine sodium therapy at the recommended dosage levels.Storage Store between 20C-25C (68F-77F) with excursions between 15C-30C (59F-86F) References 1. Evinger, J.V., and Nelson, R.W. JAVMA 314:185, 314-316, 1984. 2. Richard Nelson, DVM. Current Veterinary Therapy X. Edition by R.W.
It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction.Clinical signs of canine hypothyroidism: Not all dogs with hypothyroidism will have classical clinical signs and laboratory findings. The following list of clinical signs and laboratory findings may vary in dogs with hypothyroidism depending upon the degree and length of time of the thyroid dysfunction: Nerve and muscle function: lethargy, lack of endurance, increased sleeping.
Lloyd Laboratories Rx Medication Sold Only To Licensed Veterinarians Pharmacies. Current License Must Be On File Prior To Shipping.The TSH dose, post-dose sampling times, and interpretation of pre- and post-TSH injection responses depend somewhat on the reference laboratory used. Mode of actions: Levothyroxine sodium provided by Thyro-Tabs Caplet cannot be distinguished from L-thyroxine endogenously secreted by the thyroid gland.
Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor.Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age.
Federal law restricts this drug to use by or on the order of a veterinarian. Each tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). The structural formula for levothyroxine sodium is: Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues.The mediator from the hypothalamus which exerts a continuous influence over the pituitary release of TSH is thyrotropin-releasing hormone (TRH). Thyroid hormones influence virtually every body organ, either by their effect on growth and development or by the hormones' metabolic effects.
Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Thyro-Tabs Caplet 0.1 mg and 0.7 mg caplets contain FD C Yellow #5 (tartrazine) which has been associated with allergic-type reactions (including bronchial asthma) in susceptible.The usual maintenance dose is 0.1mg/10lb (4.5kg) once daily. Administration: Levothyroxine sodium tablets may be administered orally or placed in the food. Dosage forms available: Levothyroxine sodium tablets are available as round, color-coded, potency marked tablets in bottles of 180 or 1000 as follows: 0.1mg - yellow, 0.2mg - pink, 0.3mg - green, 0.4mg.
Normal T-4 concentrations in canine serum are: Normal (euthyroid) - 18 to 32 ng/mL (1.8 to 3.2 g/dL) Possible hypothyroid - 10 to 18 ng/mL (1.0 to 1.8 g/dL) Hypothyroid - less than 10 ng/mL ( 1.0 g/dL) The animal should be showing some clinical signs associated with hypothyroidism.Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Levothyroxine Sodium tablets will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3).
Precautions The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change.The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance.
The condition is usually primary, failure of the thyroid gland, because of lymphocytic thyroiditis or other loss of follicular epithelium and resulting atrophy of the gland. Secondary hypothyroidism is relatively rare and usually due to a destructive pituitary tumor.Dosage is then adjusted by monitoring the T-4 blood levels of the dog every four weeks until an adequate maintenance dose is established. The usual daily maintenance dose is 0.1 mg/10 lb (4.5 kg).
Other conditions in which the use of L-thyroxine replacement therapy may be contraindicated or should be instituted with caution include primary hypertension, euthyroidism, and pregnancy. Warnings: The administration of levothyroxine sodium to dogs to be used for breeding purposes or in pregnant bitches has not been evaluated.It is unknown whether such a reaction could also occur in other animals. How Supplied: Thyro-Tabs (levothyroxine sodium tablets, USP) is available as scored, color-coded caplets in 9 concentrations: 0.1 mg -yellow; 0.2 mg - pink; 0.3 mg green; 0.4 mg - maroon; 0.5 mg - white; 0.6 mg - purple; 0.7 mg - orange;.