Use: As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include: primary (thyroidal secondary (pituitary and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism.Comment: -The age, general physical condition, cardiac risk factors, and severity of myxedema and duration of myxedema symptoms should be considered when determining the starting and maintenance dosages. Use: Myxedema coma Usual Geriatric Dose for Hypothyroidism ELDERLY PATIENTS WITH CARDIAC DISEASE : -Initial dose: 12.5 to 25 mcg orally per day, with gradual dose increments.
Hence thyroxine carries out the job of plasma transport to all the cells in your body. Thyroid hormone cannot get through cell membranes like that of lipophilic substances. The primary function of thyroxine is to control the metabolic rate in our body.People with low level of thyroxine will have dry skin with white patches, slow reflexes, slow pulse rate, enlarged heart and slow speech. Goiter is a condition of low thyroxine level in blood and such people will have rapid weight gain, weakness, joint pain and stiffness in joints.
2 Most adults will maintain euthyroidism with a dose of thyroxine of 100-200 microgram/day. There may be a decline in thyroxine requirements in the elderly. Both brands of thyroxine currently available in Australia come from the same supplier and are identical.In areas without iodine deficiency the common causes of chronic hypothyroidism are autoimmune thyroid disease, thyroidectomy, radiotherapy (both radioiodine therapy and external beam radiotherapy congenital disorders and disorders of thyroid hormone metabolism.
Levothyroxine is used to treat an underactive thyroid (hypothyroidism). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery.Otherwise healthy patients who have recently undergone thyroidectomy or radioiodine treatment for thyrotoxicosis can immediately start at or just below their predicted daily replacement dose of thyroxine 100-200 microgram. Elderly patients and those with known heart disease should start with a daily dose of thyroxine 25 microgram for 3-4 weeks with a reassessment of their.
Take this medication with a full glass of water unless your doctor directs you otherwise. If you are taking the capsule form of this medication, swallow it whole. Do not split, crush, or chew.-The peak therapeutic effect of this drug may not be attained for 4 to 6 weeks. Usual Pediatric Dose for Hypothyroidism CONGENITAL OR ACQUIRED HYPOTHYROIDISM : -Neonatal: 10 to 15 mcg/kg/day; if patient is at risk for development of cardiac failure, begin with a lower dose.
This is increased at intervals of 3-4 weeks until the predicted dose is reached. Patients should feel some symptomatic improvement within two weeks of starting thyroxine. It may take 3-4 months for the full benefit of the drug to become apparent and for the TSH to normalise.-This drug should be taken at least 4 hours apart from drugs that are known to interfere with its absorption. -The peak therapeutic effect of this drug may not be attained for 4 to 6 weeks.
Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, with or without the presence of goiter.Regular monitoring of TSH and thyroxine is recommended when starting therapy or changing the dose. -This drug should be taken in the morning on an empty stomach with water, at least one-half hour before any food is eaten.
Repeat testing every six weeks is appropriate until the dose is stabilised, however if the patient is approaching euthyroidism and is feeling well this interval can be increased. After the dose is stabilised an annual TSH measurement is usually adequate monitoring unless a problem arises.It is helpful to consider if the patient's symptoms are likely to be due to hypothyroidism before prescribing thyroxine and to tell them if you suspect that some of their symptoms are unlikely to respond.
If the patient discovers they have missed one (or more) doses they can take the missed doses in conjunction with their usual dose over the next few days. The absorption of thyroxine may be reduced by cholestyramine, colestipol, aluminium hydroxide, ferrous sulfate and possibly fibre.The use of lithium and iodine-containing preparations (such as amiodarone) can cause a drug-induced hypothyroidism. Providing patients with a copy of the laboratory results which confirm their need for thyroxine often proves helpful for the patient and future treating doctors.
Thyroid disease and what medication/ dosage that works to alleviate symptoms is just as individual as you are. Barb's right when she said the healing takes time. I think you are doing the right thing, going up slowly and keeping track of how you feel, but try to relax a little, even though I know.Only the IV dosage form should be used for this condition : IV : -Initial loading dose: 300 to 500 mcg IV -Maintenance dose: 50 and 100 mcg IV, until the patient can tolerate oral therapy.
Thyroxine can be used to control symptoms if required while recovery occurs. Lithium- and amiodarone-induced hypothyroidism are managed with thyroxine. The ongoing need for the lithium or amiodarone should be considered, but they can be continued if necessary.When there is deficiency of iodine it will automatically reduce the production of T3 and T4 hormones causing goiter. When there is increase in thyroxine this leads to a condition called hyperthyroidism.
Thyroid replacement treatment is usually taken for life. There are different brands of levothyroxine available. Do not change brands without first consulting your doctor or pharmacist. Certain medications (such as cholestyramine, colestipol, colesevelam, antacids, sucralfate, simethicone, iron, sodium polystyrene sulfonate, calcium supplements, orlistat, sevelamer, among others) can decrease the amount of thyroid hormone that is.Generally, TSH is suppressed to less than 0.1 international units per liter (mU/L and this usually requires a dose of greater than 2 mcg/kg/day. However, in patients with high-risk tumors, the target level for TSH suppression may be less than 0.01 mU/L.