Therefore, many people are encouraged to seek more permanent treatments, such as radioactive iodine treatment or surgical removal. Side effects of anti-thyroid medications include skin rash, upset stomach, drowsiness, and a bitter aftertaste.After three months into the study the patients were called in, and a second blood sample was obtained from each patient for the determination of serum levels of TSH and FT4.
Researchers speculate that either statins are improving or modifying the hyperthyroidism (possibly due to the antiinflammatory effect or they may be causing falsely low TSH levels. (This situation, where the thyroid is normal but TSH levels are low, is called pseudohyperthyroidism.) Seth D.The serum of samples were separated, and kept frozen until the end of the study. The levels of TSH were determined using ELISA method (Enzaplate N-TSH, Ciba Corning Japan).The intra-assay and interassay coefficients of variation for TSH assays were 1.28 and 5.64, respectively.
Serum FT4 concentration was measured by radioimmunoassay (RIA) using a kit from Kavooshyar (Tehran, Iran). Intra-assay and interassay coefficients of variation for this assay were 2.24 and 5.65, respectively. Data, presented as meanSD, were analyzed using paired t test.As the variables (TSH and FT4) were normally distributed, paired t test was used to compare the mean value of TSH or FT4 before and after the administration of simvastatin. There wasnt seen any significant difference in serum levels of TSH or FT4 before and after simvastatin use (P0.77 and 0.76, respectively).
Abstract Background: Statins, such as simvastatin, are the drugs of choice for the treatment of hypercholesterolemia. On the other hand hypercholesterolmia can occur in hypothyroid patients, who receive levothyroxine. There are few clinical case reports in regards to drug interaction between levothyroxine and lovastatin or simvastatin, indicating decreased levothyroxine effects.Rare but serious side effects include sore throat, fever, chills, jaundice, decreased white blood cells, and liver disease. Your doctor may also prescribe a medication called a beta blocker (a drug usually given for high blood pressure) to block the action of thyroid hormone in your body.
Gullu S, et. al. "In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis." Eur J Endocrinol. 2005 Jul;153(1 41-8 Photo: m).7 - 9 Moreover, carbamazepine and phenytoin could increase the metabolism of thyroxine via enzyme induction. 10. There are a few clinical case reports, which have demonstrated the interaction between statin drugs and levothyroxine.
Since these medications simply supplement a hormone that is missing, the only real safety concern is ensuring that you take the right amount. Therefore, your doctor will need to regularly check your thyroid and TSH levels to make sure you are receiving the correct dosage.Remember to tell your doctor about any other medications you may be taking, since certain drugs can interact with your thyroid medication. These include oral contraceptives, estrogen, testosterone, certain anti-seizure medications, cholesterol-lowering medications (statins) and some antidepressants.
By Mary Shomon Updated December 04, 2014. Patients with a low TSH who are taking statin drugs - drugs to lower cholesterol - are three to four times likely to have normal radioiodine uptakes and scans that patients not taking a statin drug.Yandell, William C. Harvey, Neil J. Fernandes, Patrick W. Barr, Mark Feldman. Thyroid. October 1, 2008, 18(10 Interestingly, there is also evidence that the statin drug simvastatin (Zocor) can improve Hashimoto's Thyroiditis.
11 Since statin drugs and thyroxine are frequently prescribed together, it is necessary to assess the interaction between them. Therefore, the present study was designed to evaluate the effect of adding simvastatin, which is used in the treatment of hypercholesterolemia in hypothyroid patients, to thyroxine on serum levels of TSH and FT4, as two important.Afterwards, she gradually felt tired, complained of abdominal pain, and had an increased serum level of TSH and a lower than normal limit of FT4. Increasing the dose of levothyroxine to 900 g/week did not lead to the improvement in the patient's symptoms.
Data were analyzed using statistical Package for Social Sciences (SPSS, version 16). A p value of 0.05 was considered as the level of statistical significance. Results Fifty seven patients who had fulfilled the study inclusion and exclusion criteria were enrolled.After discontinuation of simvastatin, the symptoms of the case resolved slowly, and the TSH level returned to normal.14 The second case was a man (81 years old) whose TSH levels increased to 11.76 IU/L, and FT4 was lower than normal levels.
I was diagnosed with a TSH of 4.70. I am now on 62.5 mcg Synthroid. I was on 50 mcg Synthroid and it got my TSH to 2.77. I AM STILL MISERABLE.Sixteen patients did not return for follow up, and were withdrawn from the study. The remaining patients (n41) including 38 females and three males did complete the study. The age of them was years.
Less achy, but still sitting around all day (not that I want to be sitting all day either). I'll tell you what my doctor is doing for me: My endo wants my TSH between 1 and 2.In addition, remember to take your thyroid medication at the same time of day, and do not stop taking your medication without first discussing the decision with your doctor. Many people need to take thyroid medication for the rest of their lives.
Forty one patients (38 females and three males) were included in the study. The age of participants was years. The patients' total serum cholesterol and triglyceride were and 153.06 9.47 mg/dl, respectively.Certain foods can also interfere with your bodys absorption of thyroid hormone, including iron, calcium, and soy. If you are pregnant or may become pregnant, it is perfectly safe to continue taking your thyroid medication.
Key Words: Simvastatin, levothyroxine, drug interaction, thyroid stimulating hormone, free thyroxine. Introduction Levothyroxine is the best drug for the treatment of hypothyroidism. 1 The clinical and laboratory tests have played an important role in the assessment of effects of levothyroxin, and the relief of signs and symptoms of hypothyroidism.When taken appropriately, these medications can control hyperthyroidism in just a few weeks; however, the main problem with anti-thyroid medications lies with the fact that the underlying problem returns once they are discontinued.
This study aimed at determining possible interaction between simvastatin and levothyroxine in hypothyroid patients by assessing serum levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4 the two important laboratory indices for levothyroxine therapy.Some other drugs can cause changes in the functional activity of thyroid. Lithium, amiodarone and interferon are among the well-known drugs that can cause thyroid disorders. 4 - 6 On the other hand some drugs have effects on the pharmacokinetic of levothyroxine in human.
It is important for pregnant women to maintain appropriate levels of thyroid hormone in the body to provide the healthiest environment for fetal development. When you first learn that you are pregnant, you should contact your doctor so that s/he can check your thyroid hormone and TSH levels; these levels should also be checked once.The first report of interaction, performed by Demke and colleagues, was in a patient taking thyroxine (0.125 g/d). They showed that after starting lovastatin, a statin drug, the efficacy of thyroxine, as indicated by clinical and biochemical measures, decreased significantly.
11 Also, there were two case reports of interaction between simvastatin and thyroxine. The first one was a 75-year-old hypothyroid woman whose thyroid status was well-controlled with levothyroxine (800 g/wk). Because of hypercholesterolemia she began taking simvastatin (10 mg/d).Patients who were taking levothyroxine (in the range of 50-150 g/d) and simvastatin for the treatment of hypercholesterolemia (total cholesterol more than 200 mg/dL) were included in the study. The exclusion criteria for the study were: patients who used to take any drugs that had known effects on the metabolism of thyroxine (either inhibition or.
Well, I am pretty miserable. My legs are less swollen (good thing but now I am getting some depression that did not exist before. I am impressed you work out and exercise - I sure could not do that.If a patient did experience any problem or adverse effect that might be related to simvastatin during the study period, he/she was withdrawn from the study and the drugs were discontinued.