The chemical structure of thyroxine is.
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The placebo group showed no changes in thyroid function or peripheral indices of thyroid hormone action. In the thyroxine-treated group, serum lipids and the mean systolic time interval did not change, but the systolic time intervals became normal in the 5 patients with the most abnormal baseline values.
Thyroxine is formed by the molecular addition of iodine to the amino acid tyrosine while the latter is bound to the protein thyroglobulin. Excessive secretion of thyroxine in the body is known as hyperthyroidism, and the deficient secretion of it is called hypothyroidism.
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Symptoms improved in 8 of 14 patients receiving thyroxine and in 3 of 12 patients receiving placebo ( p 0.05). L -Thyroxine therapy may be useful for patients with subclinical hypothyroidism with abnormal myocardial contractility or symptoms consistent with mild hypothyroidism, or both.
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Pharmacokinetics Absorption Bioavailability is 48 to 79. Fasting increases absorption. Effective by parenteral route. Distribution More than 99 protein bound. Elimination The t is 6 to 7 days for T 4.
The following guidelines are recommended: Children older than 12 yr of age (growth/puberty complete) PO 1.7 mcg/kg/day. Children older than 12 yr of age (growth/puberty incomplete) PO 2 to 3 mcg/kg/day.
Dosage and Administration Individualize dosage. Infants and Children In infants with congenital or acquired hypothyroidism, institute therapy with full doses as soon as diagnosis is made. In children with chronic or severe hypothyroidism, an initial oral 25 mcg/day dose is recommended with increments of 25 mcg every 2 to 4 wk until desired effect is.
( T 4 ; L-thyroxine ) Pronunciation: lee-voe-thigh-ROX-een SO-dee-uhm Class: Thyroid hormone Trade Names Levothroid - Tablets 0.025 mg - Tablets 0.05 mg - Tablets 0.075 mg - Tablets 0.088 mg - Tablets 0.1 mg - Tablets 0.112 mg - Tablets 0.125 mg - Tablets 0.15 mg - Tablets 0.175 mg - Tablets 0.2 mg.