Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, with or without the presence of goiter.
Detailed Levothyroxine dosage information for adults, the elderly and children. Includes dosages for Hypothyroidism, TSH Suppression and Myxedema Coma; plus renal.
Hypercholesterolemia. Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase. Contraindications Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated.
Myxoedema coma is a medical emergency with high mortality. In this study, clinical response and plasma variations of thyroid hormones were analysed in 7 patients, 6 presenting with myxoedema coma and one with myxoedema ileus.
These patients were treated with intravenous or oral l-thyroxine (l-T4). 1000 mu l-T4 iv were administered in two patients. Within 3 h, plasma T4 and triiodothyronine (T3) reached a peak upper normal range, then diminished slowly during 5-9 days.
In fact, recent evidence pointed out the role of gastric acid secretion on the subsequent intestinal absorption of thyroxine in relation with the timing of food ingestion as well as with pH impairment associated to frequent gastric disorders like Helicobacter pylori infection and gastric atrophy.
Sodium levothyroxine is one of the most prescribed drugs all over the world. Oral thyroxine treatment is often used lifelong and the search for optimal daily dose may be a challenge for the physician.
This drug is contraindicated if the serum TSH is already suppressed due to the risk of precipitating overt thyrotoxicosis. Usual Adult Dose for Myxedema Coma. Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism, and may result in unpredictable absorption of the oral dosage form of this drug from the GI.
Learn about Thyroxine L Tablets for animal usage including: active ingredients, directions for use, precautions, and storage information.
Find patient medical information for L-Thyroxine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
-This drug should be taken in the morning on an empty stomach with water, at least one-half hour before any food is eaten. -This drug should be taken at least 4 hours apart from drugs that are known to interfere with its absorption.
1. Intensive Care Med. 1991;17(1 16-8. Myxoedema coma: response of thyroid hormones with oral and intravenous high-dose L-thyroxine treatment).
Use: As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include: primary (thyroidal secondary (pituitary and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism.
Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age.
For purposes of comparison, 0.1mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65mg) of desiccated thyroid. Thyroxine L Tablets Indications Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in the dog.
L-thyroxine (T 4) and L USP, compared to an equal nominal dose of oral levothyroxine sodium solution, The dose of Levothyroxine Sodium Tablets.