It is essential that prescribers and pharmacists convey this information to patients in order that therapeutic efficacy may be maximised. References 1. AHFS drug handbook. 2nd ed. Bethesda (MD American Society of Health-System Pharmacists, Lippincott Williams Wilkins; 2003.
The tablets have pharmaceutical properties which can impair the patients management. Discussing the correct use and storage of the tablets is an important part of prescribing thyroxine. Availability Synthetic preparations of thyroxine contain the laevo isomer of thyroxine, usually as the sodium salt.
Take this medication with a full glass of water unless your doctor directs you otherwise. If you are taking the capsule form of this medication, swallow it whole. Do not split, crush, or chew.
Tell your doctor if your condition worsens or persists after several weeks of taking this medication. What conditions does L-Thyroxine treat?
N Engl J Med 2001;. Conflict of interest: none declared Self-test questions The following statements are either true or false ( click here for the answers ) 1. The dose of thyroxine should be decreased in patients with renal failure.
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Treatment of hypothyroidism with once weekly thyroxine. J Clin Endocrinol Metab 1997;. 4. Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook Pty Ltd; 2004. Further reading Toft AD. Clinical practice. Subclinical hyperthyroidism.
1 The expiry date for Australian manufactured thyroxine tablets is one year from the date of manufacture. There are 200 tablets in a bottle, so it is possible that patients on half tablet doses will not finish the bottle before the stock expires.
This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels. How to use L-Thyroxine Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast.
Antacids, iron salts, calcium carbonate (milk sucralfate, cholestyramine and soy-based formulas reduce the absorption of thyroxine. Conclusion There are significant stability, absorption and drug interaction issues surrounding the use of thyroxine.
This is reduced to 34 days in hyperthyroidism and prolonged to 910 days in hypothyroidism. Thyroxine has a full therapeutic effect 34 weeks after starting treatment and will continue to have a therapeutic action for 13 weeks after treatment stops.
Nonetheless, if breast milk is used to deliver the thyroxine, it should be used consistently, in order to minimise any variation in absorption. Onset and duration of action. The half-life of thyroxine in euthyroidism is 67 days.