An iodine-containing hormone, C15H11I4NO4, produced by the thyroid gland, that increases the rate of cell metabolism and regulates growth.
Once inside the nucleus, the hormone binds its receptor, and the hormone-receptor complex interacts with specific sequences of DNA in the promoters of responsive genes. The effect of the hormone-receptor complex binding to DNA is to modulate gene expression, either by stimulating or inhibiting transcription of specific genes.
Other Effects: As mentioned above, there do not seem to be organs and tissues that are not affected by thyroid hormones. A few additional, well-documented effects of thyroid hormones include: Cardiovascular system : Thyroid hormones increases heart rate, cardiac contractility and cardiac output.
Thought to be a chemical component) thyroxine A hormone made in the thyroid that is important for growth and mental development. Thesaurus Antonyms Related Words Synonyms Legend: Noun 1. thyroxine - hormone produced by the thyroid glands to regulate metabolism by controlling the rate of oxidation in cells; "thyroxine is 65 iodine" thyroid hormone.
Thyroid Hormone Receptors and Mechanism of Action. Receptors for thyroid hormones are intracellular DNA-binding proteins that function as hormone-responsive transcription factors, very similar conceptually to the receptors for steroid hormones. Thyroid hormones enter cells through membrane transporter proteins.
Additionally, many of the effects of thyroid hormone have been delineated by study of deficiency and excess states, as discussed briefly below. Metabolism : Thyroid hormones stimulate diverse metabolic activities most tissues, leading to an increase in basal metabolic rate.
Transcription of some myosin genes is stimulated by thyroid hormones, while transcription of others in inhibited. The net effect is to alter the ratio toward increased contractility. For additional details on mechanism of action and how these receptors interact with other transcription factors, examine the section.
Your thyroid gland is a small gland, normally weighing less than one ounce, located in the front of the neck. It is made up of two halves, called lobes, that lie along the windpipe (trachea) and are joined together by a narrow band of thyroid tissue, known as the isthmus.
Aug 25, 2009. The thyroid secretes two major hormones, thyroxine and. metabolic rate of the body. functions and energy metabolism are regulated by.