3 It has been documented for many years, most recently in India, that excessive fluoride might cause thyroid disturbances similar to those observed in iodine deficiency, even in individuals with adequate iodine intake.
Nelson JC, Clark SJ, Borut DL, et al. Age related changes in serum free thyroxine during childhood and adolescence. J Pediatr. 1993;. Fisher DA. Physiological variations in thyroid hormones; physiological and pathophysiological considerations.
Clin Chem. 1996;. Faglia G, Beck-Peccoz P, Piscitelli G, et al. Inappropriate secretion of thyrotropin by the pituitary. Horm Res. 1987;. Ohzeki T, Hanaki K, Motozumi H, et al. Refractoriness at peripheral and pituitary receptors in general and pituitary types of thyroid hormone resistance.
In: Klee. GG, ed. Clinics in Laboratory Medicine: Pathophysiology of Thyroid Disease. Philadelphia, PA: W.B. Saunders Company;. Ross DS. Subclinical hyperthyroidism: possible danger for overzealous thyroxine replacement therapy. Mayo Clin Proc.
1 Soft tissue involvement in fluoride toxicity is well established. In the past, the toxic effects of fluoride on the thyroid gland were noticed based on clinical experience gained through the treatment of Graves disease.
Results: All subjects with dental fluorosis had serum levels of thyroid hormones (FT3, FT4, and TSH) within the normal range, with the exception of 1 individual, who had elevated levels of TSH.
MATERIAL AND METHODS The study included total sample size of 75 subjects. The study group comprised of 65 dental fluorosis subjects, who were selected through school dental camps. Selected study areas included those areas where iodized salt was typically accessible and consumed.
Thorough oral examinations were done under natural light. Dental fluorosis was recorded using Dean's index (1942 according to World Health Organization (1999) criteria. Recording was made on the basis of the two teeth that were most affected.
An additional control group was comprised of 10 subjects without dental fluorosis. The drinking water fluoride levels of the study populations were analyzed. Serum free FT3, FT4, and TSH levels of both groups were assessed.
If the two teeth were not equally affected, the score of the less affected of the two was recorded. Details pertaining to dietary and drinking habits were recorded. Thorough clinical examination was done to assess any obvious enlargement of the thyroid gland.
Unfortunately, statistical comparison of thyroid hormone levels between the study and cont.